Can't speak regarding couples, but the gay area of Patong is centred around the Paradise Complex off Rat U-Tit/2nd Rd. Ladyboys can be found almost anywhere, though specifically Soi Crocodile off Bangla and the Soi next to the Tiger Complex (especially Cocktails & Dreams). Another great place to Get to is Tootsies LB Massage, I would suggest this establishment for a introduction to the other side ... ask for Get.