First Suggestion: Have Fun & Happy Hunting!
Second Suggestion: Don't drive across the border. Walk across the border and take a taxi. Ask the driver to take you to Adelita's. If he tries to steer you somewhere else, tell him if he won't take you to Adelita's, you are going to find another cab who will. (Some of the cabbies will try to take you to a place such as Purple Rain where they will get a commission for getting you there.)
Once you are at Adelita's, walk in, sit down, and enjoy the view (and maybe more than just the view) of the Bar Girls (BGs). By all means, feel free to leave Adelita's and walk around the block that Adelita's is on. There you will see the Street Girls (SGs). Also check out Hong Kong (far too damned loud for my eardrums but definitely rocking), Chicago Club (dead during the day but still something to see), and one or two of the other bars in the area.
Far too much has been written about La Zona for me to go into detail here re: Which is Better, BGs or SGs? Adelita's or Hong Kong or Chicago Club or Bar Tropical or YouNameYourFavoriteBar?
Third Suggestion: If bars and the streets are not to your liking, consider using one of the escort agencies. There are a few well-established agencies that will bend over backwards to make your visit memorable. There are also a few newer agencies that are still finding their niches but offer discounts, some of which are screaming good deals.
Fourth Suggestion: Think safety. Stay alert, don't take too much money, and don't get so drunk you become an obnoxious target. Be a gracious guest and a tribute to the Good Ol' U. S. of A.
Fifth Suggestion: Have Fun & Happy Hunting! Oh, wait. I'm repeating myself. I guess that's all this vet can help you with for starters. You'll have to experience La Zona yourself to learn the rest of the ropes.
Enjoy!