This one bothers me

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U.S sales of Actos have risen steadily โ€” hitting $3.4 billion last year โ€” as Avandia's reputation has soured. Global sales of Avandia have fallen from a peak of $3.2 billion in 2006 to $1.2 billion last year.

In the U.S., more than 2.6 million patients filled prescriptions for Avandia last year, and some experts worry that those currently taking the drug may continue using it despite the risk of heart attack.

Wow that is a lot of billions down the drain for Glaxon.
 
See, it is drugs like this that make it difficult to get new (and often) much needed drugs to market. I think just about any medication comes with side effects.

Just look at all the dick pills yet guys take them by the millions?

There is one (not sure of the name) that is reminiscent of the movie "The Fugative" with Harrison Ford that is used during open heart surgery but causes severe liver or kidney problems. not sure if it is still on the market though.....

I guess Glaxo didn't pay off the right people?
 
The thing is that doctors love to prescribe and Joe Public just doesn't ask enough questions to be informed.

Big Pharma then reaps the rewards.
 
I think Glaxo paid off exactly the right people...they got a dangerous drug to market and made millions while people died.

The FDA approval process is obviously suspect, at best...this has happened several times over the last ten years or so. I always ask for the older, more-established drug when I'm getting a prescription.
 
Most of Joe Public would also prefer to pop a pill than to eat right and exercise.
 
When your right your right.

Exercising and staying away from the great Canadian diet are asking a little much from the masses don't you know.
 
In some cases maybe but not necesarrily for something like type 2 diabetes. Both my parents have it and its a desease that progresses with age. My father is 70, 5'11" and has a 34" waist which I'm guessing a lot of guys half his age would envy. He was just switched to injecting insulin because the oral meds just stopped working. The injecting is difficult and somewhat dangerous in itself.

My mom's 5'7" and weighs 140ish which isn't bad for 65 and is on Metformin and Junuvia and she could have easily been perscribed something like Avandia. This is the last step before insulin injections. I pretty much have this to look forward to at some point given the genetics.

While it's popular to automatically state that pharmaceutical companies are quite happy to kill people rather as long as they make a profit I think it is erroneous. What should not be forgotten is that diabetes untreated is a far greater killer and without these same companies death rates would be significantly higher.

The question of whether you approve a drug early after a year or two of clinical trials or wait for years and years of testing is a bit of a dilema. In many cases (diabetes, cancer to name two) more people will die by delaying. Someone very close to me is taking clinical trial cancer drugs at Princess Margerat. Patient number 18 after the mice so to speak. This is a last resort after chemo , surgery etc. If they work how long would you wish to delay release to others?

On the other side I also read today since 2001 or 2002 breast cancer rates have declined by 10%. This corresponds with the first revelation of the link between hormone therapy and breast cancer and the subsequent dramatic reduction of use of those drugs.

Not always such an easy answer
 
It goes as no surprise... my opinion of drug companies has just been further solidified.

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I didn't mean to imply that I think all illnesses are the result of life choices, not at all. My mom was the most conscientous person I've ever known about her health, but that didn't stop cancer.

I don't agree that it's erroneous when a company hides data showing their product is dangerous. If I knowingly gave someone a substance likely to injure them, without revealing the risk beforehand, I think that would be considered criminal. The fact that their drug does benefit some people doesn't make it okay for Glaxo to be deceptive.
 
If they have been deceptive I agree with you. But they haven't been charged and/or convicted which they should be if they have deliberately deceived the FDA and others. Throw them all in jail after the trial.

But my point was its not always black and white plus I'm leary of convicting anyone based on today's version of journalism which tends to leave out a hell of a lot more information than a GlAXO does.
 
This was the part of the article to which I was referring. The FDA bears responsibility as well.
 
I think gravity up there says it best:

Is it better to do a 10 yr study on the ultimate risks of a drug while people die of the disease it's supposed to fight?

For example: (not sure the status of it at this point) there was a "wonder" drug that was being developed to fight aids and HIV. Aids patients were dropping like flies and begging to be put on the drug as a trial yet the various drug FDA type ministries etc were saying no, you can't, die while we determine whether it is safe or not....so, they have a drug that might harm you, but at least you'll be alive or the trade off is die of the disease...

I also think insinuating that popping a pill instead of eating right and exercising is a pretty narrow minded view. Take me for instance: genetically, I am prone to high cholesteral. My whole family is. I rarely eat fried foods (think I had something fried last week and then that was the first time in 3 months), everything I eat is low or no fat, yet my cholesteral is still high. When I was first diagnosed I went on a strick diet of rice cakes (aka styrofoam), raisons, fruit only, and NO fat of any kind for 2 months. My LDL dropped by 2 points, and my weight dropped 10 lbs. Sure, I could lower my cholesteral to normal levels, but I'd die of starvation.....

Another example are people who contracted the HIV virus via blood transfusions. I guess they should just roll over and die because it was a lifestyle choice to need blood in the first place?

I did a LOT of work with Eli Lilly, Glaxo and others and my contacts there were in a constant battle to develope new drugs to fight diseases with no side effects. You have to weigh the pros and cons of a drug and make the determination whether you want to die early, or risk the side effects.

I mean, you could choose the "all natural" way of treating the disease: death. It's the second most natural thing we do....
 
Thisyou get this from the Internet? :???:. Sorry papa, a low blow. We still love you :tongue:
 
If they weren't hiding it from the FDA who were they hiding it from? Again, you may very well be right but without reading the source document myself( senate hearings transcripts) I'm still relying on a reporter so while it raises alarm bells I'm not quite ready to hang anyone yet. I will never take this drug though.

Since 2007 Health Canada has said this drug shouldn't be taken unless a patient can't tolerate any other. This sounds to me as if the info has been readily available for quite a while.

In any event the added publicity is good because it warns patients.
 
I didn't see any where in that article that said people died from the drug use, it states repeatedly that there are high risks, can anyone point out where it says someone died?

I take Lipitor for my high cholesteral and there are risks involved in that (liver enzymes)
 
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  35. bnwellness_wilson:
    We have 4 young girls are working today, young pretty Lily 25โ€™s with curve body and young student Taiwanese 25โ€™s slime open mind, young flirty Tina 30โ€™s with sexy body open mind and sweet GFE Lina are providing deep tissue massage, pls call 4163985777 book appointment and walk in always welcome,back entrance and parking available, 350 Wilson Ave North York
  36. Lilyspa1:
    Lily Spa : Friday Schedule โค๏ธโค๏ธ SuSu ( Asian )Slim , ๐Ÿ˜๐Ÿ˜Porn Service ๐Ÿฉท๐ŸฉทElena 22, Latino French, 36 DDD and ๐Ÿ‘๐Ÿ‘ASS, ๐Ÿ’‹๐Ÿ’‹Yuki 24, Korean Slim , ๐Ÿ˜ˆbbbj , DFk ๐Ÿ”ฅDuo ๐Ÿ”ฅ,โ˜Ž๏ธ 6475318288
  37. Moneylee:
    All season wellness center : New Young girl big breasted beautiful buttocks charming temperament big boobs Mia๏ผŒyoung girl pretty face nice figure Thai deep massage Aad,Young girl big breasted beautiful buttocks charming temperament big boobs Yoyo,Young girl Big breasted saucy naughty Ella ,Enchanting sexy petite deep massage Sherry ๐Ÿ address: #5-30 Rambler dr Brampton ,Ontario L6W 1E2โ˜Ž๏ธ4376655510 ๐Ÿ‘…๐Ÿ‘…๐Ÿ‘„๐Ÿ‘„๐Ÿฆต๐Ÿฆต๐Ÿˆต๏ธ๐Ÿˆต๏ธ
  38. Moneylee:
    Full season wellness center: New Young girl big breasted beautiful buttocks charming temperament big boobs Ivy , Young girl pretty face big boobs nice figure deep massage Jessica ,Young girl Big-breasted big Big boobs big butts May, Young beautiful face sexy body and good deep massage Maggie,Enchanting sexy petite deep massage Mary . ๐Ÿ  2560 Shepard Ave Mississauga unit 1 โ˜Ž๏ธ 4379857899 ๐Ÿ‘…๐Ÿ‘…๐Ÿฆต๐Ÿฆต๐Ÿˆต๏ธ๐Ÿˆต๏ธ๐Ÿ‘„๐Ÿ‘„
  39. Red_Pearl_Spa:
    โค๐Ÿ’‹4385 Sheppard Avenue east, unit 5 ๐Ÿ”บ๏ธ๐Ÿ’‹โฃ๐Ÿ’‹๐Ÿ”ดFriday, ๐Ÿ’ž๐Ÿ’‹ Kelly, ๐Ÿ’–today for an amazing treatment... 5'5", long light brown hair, at least C's...๐Ÿ’‹โฃ โ˜Ž๏ธ 647 352-1588โ˜Ž๏ธ
  40. wilson holistic centre:
    ๐Ÿ’•๐Ÿ’•Beautiful Korean girl working at 382 Wilson Ave ๐Ÿ’•๐Ÿ’•โ˜Ž๏ธโ˜Ž๏ธ416-840-0071โค๏ธโค๏ธ
  41. Soul Relax Spa:
    โœจ Looking for a relaxing escape? โœ… Click Here Meet๐ŸŒธKim๐ŸŒธTina๐ŸŒธIvyCall us today for the best treatment and service experience. Click on our Username and FOLLOW US for updates ! Call now โ˜Ž 289 - 298 - 5662โ˜Ž๏ธ Your ultimate relaxation awaits! โœจ
  42. Annie Spa:
    ๐ŸŽ‰๐Ÿ’ANNIE SPA๐ŸŽ‰๐Ÿ’ โœ…7-1001 SANDHURST CIRCLEโœ… ๐Ÿ‘ŒSCARBOROUGH ON M1V 1Z6๐Ÿ‘Œ โ˜Ž๏ธ (647) 891-9688โ˜Ž๏ธ โ˜Ž๏ธ (416) 291-8879โ˜Ž๏ธ (FINCH & MCCOWAN) OPEN 9:30am to 9pm MONDAY to SUNDAY ๐Ÿ”ฅโœ…NEW MANAGEMENT๐Ÿ’ฏNEW GIRLS๐Ÿ”ฅ๐Ÿ”ฅ ๐Ÿ”ฅGORGEOUS NEW YOUNG ASIAN GIRLS - TODAYโ€™s ROSTER INCLUDES: ๐Ÿ”ฅ Yumi๐Ÿ˜˜๐Ÿ’‹A striking new tall gorgeous Korean model with long, flowing reddish-brown hair cascading down her back and a slender, elegant figure that exudes grace and poise. Yumiโ€™s natural confidence and allure, make her approa
  43. Golden Sunshine Spa:
    โœจClick on our Username and FOLLOW US for updates and special services ! โœ… Click Here Today๐ŸŒธCindy๐ŸŒธCindy๐ŸŒธJessica๐ŸŒธSelina๐ŸŒธNina Call us โ˜Ž 905 - 265 - 2158โ˜Ž๏ธ Your ultimate service awaits! โœจ
  44. Red Rose Spa:
    ๐ŸŒธ We have 13 hot brown girls today ๐ŸŒธ PAOLA, AMMU, KIRAN, AMANDA, SUMMER, ASHA, PREETI, ANGELINA ๐ŸŒธ 2588 Birchmount ๐ŸŒธ 2 Invergordon ๐ŸŒธ 647-702-8800 ๐ŸŒธ Please visit for a great erotic massage
  45. Lulu1980:
    Phoenix Blossom Spa ๐ŸŒน๐ŸŒน๐ŸŒน3 girls ๐Ÿ˜˜Table shower ใ€body scrub ใ€ Sea salt bath๐Ÿ‘5124 Dundas St W Etobicokeโ˜Ž๏ธ416-817-3366๐Ÿ‘ Young girl Cherry (Student)๐Ÿ˜˜๐Ÿ˜˜โ€œcharming breasts.โ€beautiful curvy hips.โ€very provocative service๐Ÿ˜˜๐Ÿ˜˜๐Ÿ˜˜, professional super Luna deep tissue massage, has therapeutic effect to loosen bones and relieve muscle pressure and will bring you unexpected service effects, she will bring you a little surprise๐Ÿ˜๐Ÿ˜๐Ÿ˜๐Ÿ˜โค๏ธ You are welcome to make an appointment at any time or walk in the
  46. luckywellness:
    Lucky Wellness Center 4379721888 295 Eglinton Ave E,Unit 7,Mississauga Kiki and Judy are at work. They are both young and pretty. They are great at deep and relaxing massages.
  47. DareDevil:
    ARIA WELLNESS โ™ฅ๏ธADDRESS: 360 HWY 7, UNIT #6, RICHMOND HILL,647-222-5683 (PHONES CALL ONLY, NO TEXT'N AVAILABLE) โ™ฅ๏ธTODAY'S Schedule!โ™ฅ๏ธ Loaded lineup with Young Beautiful Girls : New Girl Joy, Ellagant Ella, Hottie Hattie, Magical Mia and Work out๐Ÿ‹๐Ÿšด๐Ÿ’ช Babe Amy! BUY 10 HOURS (GET 11 HOURS) **TODAY'S PICK OF THE DAY IS ๐Ÿฌ๐ŸญHattie๐Ÿฌ๐Ÿญ**
  48. Lulu_Villa_Spa:
    Sami is a gorgeous model type Vietnamese Girl Natalie filipina mixed Petite girl Jessica Pretty Girl with amazing personality and super easy to get along with. Sasa friendly Vietnamese Judy is a gorgeous model type Vietnamese Girl
  49. EMSpa_schedule:
    Tomorrow's sneak peek: On Friday April 25, 2025, our attendants will be Cici ๐Ÿ˜˜, Opal ๐Ÿ˜˜, Vicky ๐Ÿฅฐ, Carla โค and Ada ๐Ÿฅฐ. Call us at โ˜Ž๏ธ(905) 479-6668โ˜Ž๏ธ to book!
  50. SL East Spa:
    ๐Ÿ’†โ€โ™€๐Ÿ’–Terrific Thursday ๐Ÿ’– Ultimate destination for Asian massages๐ŸŽ‰ Two fab spots: SL Richmond Hill & SL West Oakville โœจ Your passport to paradise with 9 enchanting girls fr China, HK โ€” ๐Ÿ†•Tiffany, Joey, Julie, Aaliyah, Coco, Yui, Meghan, Michelle & New 34D Jasmineโ€”โ€” ready to pamper you๐ŸŽ๐Ÿ Ring us ๐Ÿ“ž647-695-6354 or text us ๐Ÿ“ฑ647-578-8169โœจ 160 East Beaver Cr., Unit 12, RichmondHill ๐Ÿ’ฐWhere Eastern charm meets Western comfort - your bliss awaits๐Ÿ™Œ
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